Genome Assembly Services

Reference-quality genome assembly using cutting-edge long-read sequencing and Hi-C technology

Platinum Standard Assembly

Total Genomics Solution specializes in producing reference-quality genome assemblies that go beyond fragmented drafts. Our approach combines the best sequencing technologies with advanced bioinformatics expertise to deliver chromosome-scale assemblies.

Through our strategic partnership with Phase Genomics, we leverage Hi-C (Proximity Ligation) technology to scaffold contigs into complete chromosomes, producing assemblies that serve as gold standards for research communities.

Our Approach

1. Long-Read Sequencing

PacBio HiFi or Nanopore ultra-long reads provide the foundation for high-quality contigs, resolving repetitive regions and structural variants that short reads cannot handle.

2. Hi-C Scaffolding

Phase Genomics Hi-C technology captures the 3D structure of DNA, enabling accurate chromosome-scale scaffolding by determining which contigs belong together and their correct order.

3. Error Correction

Illumina short reads provide high-accuracy polishing to correct any remaining errors in the long-read assembly, ensuring base-level accuracy.

4. Annotation & Analysis

Comprehensive gene prediction, functional annotation, and comparative genomics analysis to maximize the value of your assembled genome.

Proven Success

Cotton Genome (Nature Genetics 2019)

Landmark collaborative study on Gossypium barbadense and Gossypium hirsutum genome assembly, published in Nature Genetics (IF=41.4).

Our bioinformaticians served as co-first and contributing authors

Rice Genome (Communications Biology 2020)

SMRT sequencing of the Oryza rufipogon genome revealing the genomic basis of rice adaptation.

Published in Communications Biology (IF=6.3)

Medicinal Herb Genome (Molecular Plant 2017)

Panax notoginseng genome providing insights into ginsenoside biosynthesis and genome evolution.

Published in Molecular Plant (IF=16.7)

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